Oral administration of PPC enhances antigen-specific CD8+ T cell responses while reducing IgE levels in sensitized mice

Oral administration of PPC enhances antigen-specific CD8+ T cell responses while reducing IgE levels in sensitized mice

BACKGROUND For almost 2000 years it has been recognized that aqueous extracts from pine cones possess medicinal properties beneficial for the treatment of a broad variety of diseases and conditions. In this report, the ability of an orally administered poly phenylpropanoid-polysaccharide rich extract of pine cones (PPC) to suppress the generation of IgE and to significantly enhance antigen-spec...

IgE Enhances Antibody and T Cell Responses

An oral recombinant Salmonella enterica serovar Typhimurium mutant elicits systemic antigen-specific CD8+ T cell cytokine responses in mice

BACKGROUND The induction of antigen-specific CD8+ T cell cytokine responses against an attenuated, oral recombinant Salmonella enterica serovar Typhimurium vaccine expressing a green fluorescent protein (GFP) model antigen was investigated. A GFP expression plasmid was constructed in which the gfp gene was fused in-frame with the 5' domain of the Escherichia coli beta-galactosidase alpha-gene f...

Induction of homologous rather than heterologous antigen-specific CD4 T cell responses is critical for functional CD8 T cell responses in mice transgenic for a foreign antigen.

The development of a successful cancer vaccine requires the ability to break immunological tolerance to self-Ags expressed on tumor cells. The transgenic rat insulin promoter (RIP) OVA(LOW) mouse model has been reported to be hyporesponsive for both OVA-specific CD4 and CD8 T cell responses. The experiments described in the current study show that this hyporesponsiveness can be overcome by incl...

allograft-specific CD8+ T cell responses

The Rockefeller University Press $30.00 J. Exp. Med. 2014 Vol. 211 No. 2 297-311 www.jem.org/cgi/doi/10.1084/jem.20130902 297 T cell–specific co-stimulation blockade is an attractive alternative to traditional immunosuppression to mitigate unwanted immune responses during transplantation and autoimmunity. Owing to the limited tissue distribution of its targets, T cell co-stimulation blockade of...